In vivo and in vitro effects of bromelain on PGE2 and SP concentrations in the inflammatory exudate in rats

被引：43

作者：

Gaspani, L ^{[1
]}

Limiroli, E ^{[1
]}

Ferrario, P ^{[1
]}

Bianchi, M ^{[1
]}

机构：

[1] Univ Milan, Dept Pharmacol, I-20129 Milan, Italy

来源：

PHARMACOLOGY | 2002年 / 65卷 / 02期

关键词：

bromelain; carrageenin; prostaglandin E-2; rat; substance P;

D O I：

10.1159/000056191

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The effects of bromelain were examined in rats with subcutaneous carrageenin-induced inflammation. After oral in vivo administration, bromelain (10 and 20 mg/kg p.o.) induced a significant decrease of both PGE(2) and substance P concentrations in the exudate. When added to the inflammatory exudate in vitro, the drug (25, 50, 100 mug/ml) did not affect PGE(2) concentrations and induced an increase in the substance P levels. Our data indicate that bromelain reduces the production of two key mediators of inflammation. This effect does not seem to be related to a direct action of the drug on PGE(2) and SP released in the exudate in response to the inflammatory stimulus. Copyright (C) 2002 S, Karger AG, Basel.

引用

页码：83 / 86

页数：4

共 20 条

[1]

MU-OPIOID AND KAPPA-OPIOID RECEPTOR AGONISTS PRODUCE PERIPHERAL INHIBITION OF NEUROGENIC PLASMA EXTRAVASATION IN RAT SKIN [J].