Immunologic Therapeutic Interventions in Asthma Impact on Natural History

被引：6

作者：

Bourdin, Arnaud ^{[1
,2
]}

Humbert, Marc ^{[3
]}

Chanez, Pascal ^{[4
]}

机构：

[1] CHU Montpellier, Serv Malad Resp, Hop Arnaud de Villeneuve, Dept Resp Dis, Montpellier, France

[2] Univ Montpellier 1 & 2, CHU Arnaud de Villeneuve, INSERM, Physiol & Med Expt Coeur & Muscles U1046, Montpellier, France

[3] Univ Paris 11, Hop Antoine Beclere, Assistance Publ Hop Paris,INSERM,U999, Serv Pneumol & Reanimat Resp,Ctr Natl Reference H, F-92140 Clamart, France

[4] Aix Marseille Univ, Dept Malad Resp, AP HM, Lab Immunol,CNRS,INSERM,U1067,UMR7733, Marseille, France

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 03期

关键词：

Asthma; Immunology; Therapeutic intervention; PLACEBO-CONTROLLED TRIAL; NECROSIS-FACTOR-ALPHA; IL-5; MESSENGER-RNA; CORTICOSTEROID-DEPENDENT ASTHMA; THYMIC STROMAL LYMPHOPOIETIN; SEVERE PERSISTENT ASTHMA; GENOME-WIDE ASSOCIATION; CD8(+) T-CELLS; AIRWAY INFLAMMATION; MAST-CELLS;

D O I：

10.1016/j.ccm.2012.06.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The discovery of new pathobiological pathways involved in asthma chronicity and reliefs offers novel therapeutic avenues. Enhanced phenotyping criteria associated with simple biologic characterization allowed to test targeted interventions in selected patients. Long-term studies are de facto lacking but required to address their impact on the natural history of the disease. Here, the authors review all potential available therapeutics based on immunologic pathways involved in asthma pathophysiology during the last decade.

引用

页码：585 / +

页数：14

共 139 条

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[2]

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