Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels

被引:168
作者
Katz, J [1 ]
Flugelman, MY
Goldberg, A
Heft, M
机构
[1] Univ Florida, Coll Dent, Dept Oral Maxillofacial Surg & Diagnost Sci, Div Oral Med, Gainesville, FL 32611 USA
[2] Technion Israel Inst Technol, Lady Davis Carmel Hosp, Dept Cardiol, Haifa, Israel
[3] Technion Israel Inst Technol, Bruce Rappaport Sch Med, Haifa, Israel
[4] Ben Gurion Univ Negev, Dept Emergency Med, IL-84105 Beer Sheva, Israel
关键词
cardiovascular diseases/epidemiology; cholesterol/adverse effects; lipoproteins; LDL cholesterol/adverse effects; periodontal pockets; risk factors;
D O I
10.1902/jop.2002.73.5.494
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: Periodontitis is associated with increased prevalence of cardiovascular morbidity and mortality; however, the nature of this association is unclear. There is a rationale that indicates that the presence of periodontal pockets which can harbor pathogenic microorganisms and evoke a host response could elicit a systemic effect. The hypothesis of this study is that periodontal pockets may be associated with elevated blood lipid levels, a known risk factor for atherosclerotic disease. Methods: The periodontal health of 10,590 Israeli military service men and women was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The relationship of blood lipids and periodontal disease and CPITN index was tested, controlling for factors that are related to elevated cholesterol levels, including high body mass index (BMI), age, diastolic blood pressure, and smoking. Results: The presence of periodontal pockets was positively associated with higher cholesterol and low density lipoprotein (LDL) cholesterol blood levels in men. No significant association was found in women. Conclusions: In this large cohort study, the presence of periodontal pockets as measured by CPITN was positively associated with total cholesterol and LDL-cholesterol. The findings of the study support the reports linking increased prevalence of cardiovascular mortality among patients with periodontal disease.
引用
收藏
页码:494 / 500
页数:7
相关论文
共 46 条
[1]  
BAELUM V, 1995, J CLIN PERIODONTOL, V22, P146
[2]   Periodontal disease and cardiovascular disease [J].
Beck, J ;
Garcia, R ;
Heiss, G ;
Vokonas, PS ;
Offenbacher, S .
JOURNAL OF PERIODONTOLOGY, 1996, 67 (10) :1123-1137
[3]   Dental infections and atherosclerosis [J].
Beck, JD ;
Pankow, J ;
Tyroler, HA ;
Offenbacher, S .
AMERICAN HEART JOURNAL, 1999, 138 (05) :S528-S533
[4]   Oral disease, cardiovascular disease and systemic inflammation [J].
Beck, JD ;
Slade, G ;
Offenbacher, S .
PERIODONTOLOGY 2000, 2000, 23 :110-120
[5]   Association between periodontitis and hyperlipidemia: Cause or effect? [J].
Cutler, CW ;
Shinedling, EA ;
Nunn, M ;
Jotwani, R ;
Kim, BO ;
Nares, S ;
Iacopino, AM .
JOURNAL OF PERIODONTOLOGY, 1999, 70 (12) :1429-1434
[6]   Chronic infections and coronary heart disease: is there a link? [J].
Danesh, J ;
Collins, R ;
Peto, R .
LANCET, 1997, 350 (9075) :430-436
[7]  
DESTEFANO F, 1993, BMJ-BRIT MED J, V306, P388
[8]   Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis [J].
Dongari-Bagtzoglou, AI ;
Ebersole, JL .
JOURNAL OF PERIODONTOLOGY, 1998, 69 (08) :899-910
[9]   Invasion of human coronary artery cells by periodontal pathogens [J].
Dorn, BR ;
Dunn, WA ;
Progulske-Fox, A .
INFECTION AND IMMUNITY, 1999, 67 (11) :5792-5798
[10]   Association between periodontal disease and acute myocardial infarction [J].
Emingil, G ;
Buduneli, E ;
Aliyev, A ;
Akilli, A ;
Atilla, G .
JOURNAL OF PERIODONTOLOGY, 2000, 71 (12) :1882-1886