Haemolytic properties of some water-soluble para-sulphonato-calix-[n]-arenes

被引:87
作者
Da Silva, E [1 ]
Shahgaldian, P [1 ]
Coleman, AW [1 ]
机构
[1] CNRS, IBCP, UMR 5086, F-69367 Lyon 07, France
关键词
water-soluble macrocycle; erythrocyte; haemolytic; para-sulphonato-calix-arene;
D O I
10.1016/j.ijpharm.2003.12.008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this paper, we describe the haemolytic effect of parent para-sulphonato-calix-[n]-arenes and their derivatives bearing one pendant group at the lower rim of calix-arene towards human erythrocytes. A maximum of 30% of haemolysis has been observed for para-sulphonato-calix-[8]-arene for a concentration of 200 mM representing 300 g of calix-arene per liter of human blood, para-sulphonato-calix-[4]-arene and para-sulphonato-calix-[6]-arene show much lower haemolytic effects, 0.5 and 8%, respectively at 200 mM concentration. Coupling of a methoxy-carboxylate function at the phenolic group reduces haemolytic effects in all cases. The presence of an ethoxy-amine function increases the haemolytic behaviour for the calix-[4]-arene and calix-[6]-arene systems, but reduces the effect for the calix-[8]-arene derivatives. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:57 / 62
页数:6
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