Ankle-arm index is a useful test for clinical practice in outpatients with suspected coronary artery disease

被引:16
作者
Chang, Shih-Tai
Chen, Chien-Lung
Chu, Chi-Ming
Lin, Pi-Chi
Chung, Chang-Min
Hsu, Jen-Te
Cheng, Hui-Wen
Yang, Teng-Yao
Hung, Kuo-Chun
机构
[1] Chiayi Chang Gung Mem Hosp, Div Cardiol, Putz City, Chia Yi Hsien, Taiwan
[2] Li Shin Hosp, Div Internal Med, Taipei, Taiwan
[3] Natl Def Med Ctr, Inst Publ Hlth, Sect Hlth Informat, Taipei, Taiwan
[4] Natl Def Univ, Taipei, Taiwan
关键词
ankle-arm index; coronary artery disease-; high sensitive C-reactive protein (hsCRP); metabolic syndrome; peripheral artery disease;
D O I
10.1253/circj.70.686
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Although a low ankle-arm index (AAI) has been reported to be associated with increased risk of cardiovascular mortality in several populations, no data exist concerning the impact of AAI for outpatients with suspected coronary artery disease (CAD) in the clinical setting. Methods and Results The present study enrolled 840 outpatients (age range 35-87 years, mean age 63.9 +/- 10.2) with suspected CAD. All patients underwent AAI measurements and coronary angiography, and based on the AAI values, they were divided into group A (AAI < 0.9; n = 191; CAD positive, 181) and group B (AAI >= 0.9; n = 649; CAD positive, 509). Metabolic syndrome (MS), obesity, and level of the inflammatory biomarker high sensitive C-reactive protein (hsCRP) were compared between the 2 groups. The sensitivity, specificity, positive and negative predictive values in predicting CAD with an AAI value < 0.9 in all patients were 26.2%, 93.3%, 94.8% and 21.6%, respectively. The patients in group A was significantly older and there was a higher female-to-male ratio than in group B. The presence of hypertension and diabetes mellitus, current smoking status, and levels of low density lipoprotein (LDL)-cholesterol level, uric acid and hsCRP differed significantly between the 2 groups. Group A had a higher percentage of high LDL-cholesterol level, high waist-to-hip ratio and more positive cases of MS than group B. Multivariate logistical regression analysis showed that AAI was related to MS, high levels of hsCRP (> 3 mg/L) and uric acid (> 7 mg/dl) with odds ratios of 1.769, 3.907 and 2.580, respectively. Conclusions The AAI test is an effective tool in predicting CAD in outpatients in clinical practise.
引用
收藏
页码:686 / 690
页数:5
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