Two new alkaloids from Portulaca oleracea and their cytotoxic activities

被引：49

作者：

Tian, Jin-Long ^{[1
,2
]}

Liang, Xiao ^{[1
,2
]}

Gao, Pin-Yi ^{[3
]}

Li, Dan-Qi ^{[1
,2
]}

Sun, Qian ^{[1
,2
]}

Li, Ling-Zhi ^{[1
,2
]}

Song, Shao-Jiang ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[3] Shenyang Univ Chem Technol, Coll Chem Engn, Shenyang 110142, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 03期

关键词：

alkaloid; Portulaca oleracea; chemical constituent; cytotoxicity;

D O I：

10.1080/10286020.2013.866948

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new alkaloids named (3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone (1) and 1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one (2), together with two known compounds (7R)-N-feruloyl normetanephrine (3) and N-trans-feruloyl tyramine (4) were isolated from the air-dried aerial parts of Portulaca oleracea L. Their structures and configurations were elucidated by spectroscopic methods including 1D NMR, 2D NMR, and HR-MS techniques. In addition, compounds 1-4 were tested for in vitro cytotoxic activities against human lung (K562 and A549) and breast (MCF-7 and MDA-MB-435) cancer cell lines.

引用

页码：259 / 264

页数：6

共 16 条

[1]

The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp sativa (Haw.) Celak [J].