Tackling reproducibility in academic preclinical drug discovery

被引：44

作者：

Frye, Stephen V. ^{[1
]}

Arkin, Michelle R. ^{[2
]}

Arrowsmith, Cheryl H. ^{[3
]}

Conn, P. Jeffrey ^{[4
]}

Glicksman, Marcie A. ^{[5
]}

Hull-Ryde, Emily A. ^{[1
]}

Slusher, Barbara S. ^{[6
]}

机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

[2] Univ Calif San Francisco, Sch Pharm, Small Mol Discovery Ctr, San Francisco, CA 94143 USA

[3] Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada

[4] Vanderbilt Univ, Vanderbilt Ctr Neurosci Drug Discovery, Dept Pharmacol, Nashville, TN 37232 USA

[5] ORIG3N, Boston, MA 02210 USA

[6] Johns Hopkins Sch Med, Johns Hopkins Drug Discovery, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 11期

关键词：

D O I：

10.1038/nrd4737

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The reproducibility of biomedical research on novel drug targets has become suspect. Here, we highlight how drug discovery centres embedded in academic institutions, but with a translational imperative, can help address this reproducibility crisis.

引用

页码：733 / 734

页数：2

共 5 条

[1] The promise and peril of chemical probes
Arrowsmith, Cheryl H.
Audia, James E.
Austin, Christopher
Baell, Jonathan
Bennett, Jonathan
Blagg, Julian
Bountra, Chas
Brennan, Paul E.
Brown, Peter J.
Bunnage, Mark E.
Buser-Doepner, Carolyn
Campbell, Robert M.
Carter, Adrian J.
Cohen, Philip
Copeland, Robert A.
Cravatt, Ben
Dahlin, Jayme L.
Dhanak, Dashyant
Edwards, Aled M.
Frye, Stephen V.
Gray, Nathanael
Grimshaw, Charles E.
Hepworth, David
Howe, Trevor
Huber, Kilian V. M.
Jin, Jian
Knapp, Stefan
Kotz, Joanne D.
Kruger, Ryan G.
Lowe, Derek
Mader, Mary M.
Marsden, Brian
Mueller-Fahrnow, Anke
Mueller, Susanne
O'Hagan, Ronan C.
Overington, John P.
Owen, Dafydd R.
Rosenberg, Saul H.
Roth, Brian
Ross, Ruth
Schapira, Matthieu
Schreiber, Stuart L.
Shoichet, Brian
Sundstrom, Michael
Superti-Furga, Giulio
Taunton, Jack
Toledo-Sherman, Leticia
Walpole, Chris
Walters, Michael A.
Willson, Timothy M.
[J]. NATURE CHEMICAL BIOLOGY, 2015, 11 (08) : 536 - 541
[2] Chemical con artists foil drug discovery
Baell, Jonathan
Walters, Michael A.
[J]. NATURE, 2014, 513 (7519) : 481 - 483
[3] Drug discoverers chart path to tackling data irreproducibility
Dolgin, Elie
[J]. NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (12) : 875 - 876
[4] An open investigation of the reproducibility of cancer biology research
Errington, Timothy M.
Iorns, Elizabeth
Gunn, William
Tan, Fraser Elisabeth
Lomax, Joelle
Nosek, Brian A.
[J]. ELIFE, 2014, 3
[5] Believe it or not: how much can we rely on published data on potential drug targets?
Prinz, Florian
Schlange, Thomas
Asadullah, Khusru
[J]. NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (09) : 712 - U81

← 1 →