EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes

被引：99

作者：

Zimber-Strobl, U ^{[1
]}

Strobl, LJ ^{[1
]}

机构：

[1] Univ Cologne, Inst Genet, D-50931 Cologne, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 06期

关键词：

Epstein-Barr virus; B lymphocytes; EBNA2; Notch; RBP-J;

D O I：

10.1006/scbi.2001.0409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor.

引用

页码：423 / 434

页数：12

共 143 条

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