Biomodulatory approaches to photodynamic therapy for solid tumors

被引：166

作者：

Anand, Sanjay ^{[1
,2
]}

Ortel, Bernhard J. ^{[3
]}

Pereira, Stephen P. ^{[4
]}

Hasan, Tayyaba ^{[5
]}

Maytin, Edward V. ^{[1
,2
,5
]}

机构：

[1] Cleveland Clin, Dept Dermatol, Cleveland, OH 44195 USA

[2] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA

[3] Univ Chicago, Dermatol Sect, Chicago, IL 60637 USA

[4] UCL, UCL Inst Liver & Digest Hlth, London, England

[5] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

来源：

CANCER LETTERS | 2012年 / 326卷 / 01期

关键词：

ALA; PDT; Vitamin D; Differentiation; Porphyrin; PROTOPORPHYRIN IX ACCUMULATION; IRON-CHELATING AGENT; AMINOLEVULINIC ACID; BARRETTS-ESOPHAGUS; SKIN-CANCER; ENDOGENOUS PROTOPORPHYRIN; PAGETS-DISEASE; BILIARY-TRACT; IN-SITU; ABLATION;

D O I：

10.1016/j.canlet.2012.07.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Photodynamic Therapy (PDT) uses a photosensitizing drug in combination with visible light to kill cancer cells. PDT has an advantage over surgery or ionizing radiation because PDT can eliminate tumors without causing fibrosis or scarring. Disadvantages include the dual need for drug and light, and a generally lower efficacy for PDT vs. surgery. This minireview describes basic principles of PDT, photosensitizers available, and aspects of tumor biology that may provide further opportunities for treatment optimization. An emerging biomodulatory approach, using methotrexate or Vitamin D in combination with aminolevulinate-based PDT, is described. Finally, current clinical uses of PDT for solid malignancies are reviewed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：8 / 16

页数：9

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