Increased risk of multiple sclerosis after late Epstein-Barr virus infection - A historical prospective study

被引:5
作者
Haahr, S
KochHenriksen, N
MollerLarsen, A
Eriksen, LS
Andersen, HMK
机构
[1] RIGSHOSP,DANISH MULTIPLE SCLEROSIS REGISTRY,DK-2100 COPENHAGEN,DENMARK
[2] DANISH INST CLIN EPIDEMIOL,COPENHAGEN,DENMARK
[3] AALBORG HOSP,DEPT NEUROL,COPENHAGEN,DENMARK
来源
ACTA NEUROLOGICA SCANDINAVICA | 1997年 / 95卷
关键词
multiple sclerosis; infectious mononucleosis; Paul-Bunnell reaction; heterophile antibody; EPIDEMIOLOGY; PREVALENCE; DISEASE;
D O I
10.1111/j.1600-0404.1997.tb08153.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The objective of this study was to evaluate the association between infectious mononucleosis (IM) and multiple sclerosis (MS). In a historical prospective study we used records from the Danish State Serum Institute in which heterophile antibody tests (HA) for infectious mononucleosis were performed for all Danish patients for a number of years. Included in the analysis were 6853 HA-positive people and 12,886 HA-negative people. A search for the presence of these people in the nationwide Danish Multiple Sclerosis Registry (DMSR) was performed. Among the HA-positive people 16 cases of MS were found. The expected number for a matched Danish population was 5.70, the risk ratio being 2.81. No cases had developed MS before contracting infectious mononucleosis. Among the HA-negative people the expected number of MS patients were found. Although Epstein-Barr virus is not suggested in itself to be the cause of multiple sclerosis, a hypothesis is put forward that it is a cofactor in the pathogenesis of this disease.
引用
收藏
页码:70 / 75
页数:6
相关论文
共 23 条
[1]  
ALLISON RS, ULSTER MED J S, V23, P5
[2]  
AMBINDER RF, 1994, AM J PATHOL, V145, P239
[3]   DEMYELINATING DISEASE AFTER NEUROLOGICALLY COMPLICATED PRIMARY EPSTEIN-BARR-VIRUS INFECTION [J].
BRAY, PF ;
CULP, KW ;
MCFARLIN, DE ;
PANITCH, HS ;
TORKELSON, RD ;
SCHLIGHT, JP .
NEUROLOGY, 1992, 42 (02) :278-282
[4]  
Evans AS., 1989, Viral infections of humans, V3rd, P265
[5]   INTERACTIONS BETWEEN HERPESVIRUSES AND RETROVIRUSES - IMPLICATIONS IN THE INITIATION OF DISEASE [J].
EVERMANN, JF ;
DERSE, D ;
DORN, PL .
MICROBIAL PATHOGENESIS, 1991, 10 (01) :1-9
[6]   IS MULTIPLE-SCLEROSIS CAUSED BY A DUAL INFECTION WITH RETROVIRUS AND EPSTEIN-BARR-VIRUS [J].
HAAHR, S ;
SOMMERLUND, M ;
MOLLERLARSEN, A ;
MOGENSEN, S ;
ANDERSEN, HMK .
NEUROEPIDEMIOLOGY, 1992, 11 (4-6) :299-303
[7]  
HALLEE TJ, YALE J BIOL MED, V47, P182
[8]  
KOCH-HENRIKSEN N, 1989, Acta Neurologica Scandinavica Supplementum, V80, P1
[9]   EPIDEMIOLOGY OF MULTIPLE-SCLEROSIS - INCIDENCE AND PREVALENCE RATES IN DENMARK 1948-64 BASED ON THE DANISH MULTIPLE-SCLEROSIS REGISTRY [J].
KOCHHENRIKSEN, N ;
HYLLESTED, K .
ACTA NEUROLOGICA SCANDINAVICA, 1988, 78 (05) :369-380
[10]   EPIDEMIOLOGY OF MULTIPLE-SCLEROSIS IN UNITED-STATES VETERANS .3. MIGRATION AND THE RISK OF MS [J].
KURTZKE, JF ;
BEEBE, GW ;
NORMAN, JE .
NEUROLOGY, 1985, 35 (05) :672-678