Current status in extracorporeal immunomodulation: Immune disorders

被引：10

作者：

Bosch, T

机构：

[1] Nephrological Department, Medical Clinic I, University of Munich, Munich

[2] Nephrological Dept., Medical Clinic I, University of Munich

来源：

ARTIFICIAL ORGANS | 1996年 / 20卷 / 08期

关键词：

extracorporeal immunomodulation; plasma exchange; immune complexes; anti-neutrophil cytoplasmatic antibodies; systemic lupus erythematosus; sepsis;

D O I：

10.1111/j.1525-1594.1996.tb04567.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Today, clinicians can choose from a variety of extracorporeal immunomodulatory procedures such as plasma exchange, double filtration, immunoadsorption, chemoadsorption, photopheresis, and cytoapheresis. The mechanisms underlying extracorporeal immunomodulation (ECIM) comprise removal of pathogenic antibodies and circulating immune complexes as well as reticuloendothelial system deblockage; modification of immune complex structure and processing can be induced by changing the antigen/antibody ratio and by modulation of immune complex solubility via complement activation. Finally, cellular components like lymphocyte subsets, can be modified. Clinical examples of ECIM include lupus erythematosus, Goodpasture's syndrome, antineutrophil cytoplasmatic antibodies-mediated systemic vasculitis, myasthenia gravis, and, hypothetically, sepsis.

引用

页码：902 / 905

页数：4

共 22 条

[1] IMMUNOADSORPTION IN MYASTHENIA-GRAVIS - MECHANISMS OF ACTION, IMMUNOLOGICAL MARKERS AND CLINICAL COURSE [J].