Relationship between cadmium concentration in rice and renal dysfunction in individual subjects of the Jinzu River basin determined using a logistic regression analysis

被引:32
作者
Watanabe, Y
Kobayashi, E
Okubo, Y
Suwazono, Y
Kido, T
Nogawa, K
机构
[1] Chiba Univ, Grad Sch Med A2, Dept Occupat & Environm Med, Chiba 2608670, Japan
[2] Kanazawa Univ, Sch Hlth Sci, Dept Community Hlth Nursing, Kanazawa, Ishikawa 920, Japan
关键词
cadmium concentration in rice; renal dysfunction; dose-response relationship; food contamination; Jinzu River; cadmium poisoning;
D O I
10.1016/S0300-483X(01)00557-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the association between the Cd concentration in rice and renal dysfunction in individuals living in the Cd-polluted Jinzu River basin, using a logistic regression analysis. In the cases of logistic regression analysis for people (1) who had either resided in the present hamlet since birth or who had moved there from a non-polluted area and for those (2) who had resided in the present hamlet since birth, except for glucosuria in males, all partial correlation coefficients between the Cd concentration in rice and occurrence of abnormal urinary findings were statistically significant in both sexes. The allowable level of Cd concentration in rice was calculated by substituting the abnormality rates of urinary findings of the controls in the 40-49, 50-59 and 60-69 year age groups into the logistic regression formula for people (3). The value for subjects aged 50 years was 0.13 and 0.17 ppm for males and females, respectively, with regard to proteinuria and 0.15 and 0.10 ppm for males and females, respectively, with regard to proteinuria+glucosuria. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:93 / 101
页数:9
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