Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration

被引：438

作者：

Bravo, Roberto ^{[1
]}

Parra, Valentina ^{[1
]}

Gatica, Damian ^{[1
]}

Rodriguez, Andrea E. ^{[1
]}

Torrealba, Natalia ^{[1
]}

Paredes, Felipe ^{[1
]}

Wang, Zhao V. ^{[3
]}

Zorzano, Antonio ^{[4
]}

Hill, Joseph A. ^{[3
]}

Jaimovich, Enrique ^{[1
,2
]}

Quest, Andrew F. G. ^{[1
,2
]}

Lavandero, Sergio ^{[1
,2
,3
]}

机构：

[1] Univ Chile, Fac Med, Ctr Mol Studies Cell, Fac Chem & Pharmaceut Sci, Santiago 7, Chile

[2] Univ Chile, Fac Med, Inst Biomed Sci, Santiago 7, Chile

[3] Univ Texas SW Med Ctr Dallas, Dept Internal Med Cardiol, Dallas, TX 75390 USA

[4] Inst Res Biomed, Barcelona, Spain

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 301 | 2013年 / 301卷

关键词：

STRESS SENSOR IRE1; MITOCHONDRIAL ENERGY-METABOLISM; ER-ASSOCIATED DEGRADATION; ENDOTHELIAL GROWTH-FACTOR; CHRONIC OXIDATIVE STRESS; PANCREATIC BETA-CELLS; FACTOR-KAPPA-B; TRANSCRIPTION FACTOR; ALZHEIMERS-DISEASE; QUALITY-CONTROL;

D O I：

10.1016/B978-0-12-407704-1.00005-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

引用

页码：215 / 290

页数：76

共 390 条

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