Molecular identification of the insect adipokinetic hormone receptors

被引:232
作者
Staubli, F
Jorgensen, TJD
Cazzamali, G
Williamson, M
Lenz, C
Sondergaard, L
Roepstorff, P
Grimmelikhuijzen, CJP
机构
[1] Univ Copenhagen, Inst Zool, Dept Cell Biol, DK-2100 Copenhagen, Denmark
[2] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark
[3] Univ Copenhagen, Inst Mol Biol, Dept Genet, DK-1353 Copenhagen, Denmark
关键词
D O I
10.1073/pnas.052556499
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.
引用
收藏
页码:3446 / 3451
页数:6
相关论文
共 36 条
[1]   Structural, functional, and evolutionary characterization of novel members of the allatostatin receptor family from insects [J].
Auerswald, L ;
Birgül, N ;
Gäde, G ;
Kreienkamp, HJ ;
Richter, D .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 282 (04) :904-909
[2]   Reverse physiology in Drosophila:: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family [J].
Birgül, N ;
Weise, C ;
Kreienkamp, HJ ;
Richter, D .
EMBO JOURNAL, 1999, 18 (21) :5892-5900
[3]   CRUSTACEAN COLOR-CHANGE HORMONE - AMINO-ACID SEQUENCE AND CHEMICAL SYNTHESIS [J].
FERNLUND, P ;
JOSEFSSON, L .
SCIENCE, 1972, 177 (4044) :173-+
[4]  
Gade G, 1996, Z NATURFORSCH C, V51, P607
[5]   Hormonal regulation in insects: Facts, gaps, and future directions [J].
Gade, G ;
Hoffmann, KH ;
Spring, JH .
PHYSIOLOGICAL REVIEWS, 1997, 77 (04) :963-1032
[6]   The Oxytocin Receptor System: Structure, function, and regulation [J].
Gimpl, G ;
Fahrenholz, F .
PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :629-683
[7]   Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors from vertebrates [J].
Hauser, F ;
Sondergaard, L ;
Grimmelikhuijzen, CJP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 249 (03) :822-828
[8]   Molecular cloning, genomic organization, and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to members of the thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone choriogonadotropin receptor family from mammals [J].
Hauser, F ;
Nothacker, HP ;
Grimmelikhuijzen, CJP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :1002-1010
[9]   Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome [J].
Hewes, RS ;
Taghert, PH .
GENOME RESEARCH, 2001, 11 (06) :1126-1142
[10]   ISOLATION AND IDENTIFICATION OF ADIPOKINETIC HORMONE OF THE SILKWORM, BOMBYX-MORI [J].
ISHIBASHI, J ;
KATAOKA, H ;
NAGASAWA, H ;
ISOGAI, A ;
SUZUKI, A .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (01) :66-70