Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy

被引：205

作者：

Eapen, Mary ^{[1
,2
]}

Klein, John P. ^{[1
,3
]}

Ruggeri, Annalisa ^{[4
]}

Spellman, Stephen ^{[5
]}

Lee, Stephanie J. ^{[6
]}

Anasetti, Claudio ^{[7
]}

Arcese, William ^{[8
]}

Barker, Juliet N. ^{[9
]}

Baxter-Lowe, Lee Ann ^{[10
]}

Brown, Maria ^{[5
]}

Fernandez-Vina, Marcelo A. ^{[11
]}

Freeman, John ^{[12
]}

He, Wensheng ^{[1
,2
]}

Iori, Anna Paola ^{[13
]}

Horowitz, Mary M. ^{[1
,2
]}

Locatelli, Franco ^{[14
,15
]}

Marino, Susana ^{[16
]}

Maiers, Martin ^{[12
]}

Michel, Gerard ^{[17
]}

Sanz, Guillermo F. ^{[18
]}

Gluckman, Eliane ^{[4
]}

Rocha, Vanderson ^{[19
]}

机构：

[1] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA

[4] Hop St Louis, Eurocord, Paris, France

[5] Ctr Int Blood & Marrow Transplant Res, Natl Marrow Donor Program, Minneapolis, MN USA

[6] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

[7] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA

[8] Univ Roma Tor Vergata, Rome Transplant Network, Rome, Italy

[9] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[10] Univ Calif San Francisco, San Francisco, CA 94143 USA

[11] Stanford Univ, Palo Alto, CA 94304 USA

[12] Natl Marrow Donor Program, Minneapolis, MN USA

[13] Univ Rome, Rome, Italy

[14] Osped Pediat Bambino Gesu, Inst Ricovero & Cura Carattere Sci, Rome, Italy

[15] Univ Pavia, I-27100 Pavia, Italy

[16] Univ Chicago, Chicago, IL 60637 USA

[17] Univ Hosp Marseille, Marseille, France

[18] Hosp Univ La Fe, Valencia, Spain

[19] Churchill Hosp, Oxford OX3 7LJ, England

来源：

BLOOD | 2014年 / 123卷 / 01期

关键词：

HEMATOPOIETIC-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; ACUTE-LEUKEMIA; RETROSPECTIVE ANALYSIS; UNRELATED DONORS; COMPETING RISKS; GRAFT; RECIPIENTS; ADULTS; ANTIBODIES;

D O I：

10.1182/blood-2013-05-506253

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles. NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLA-matched units. The observed effects are independent of cell dose and patient age. These data support allele-level HLA matching in the selection of single UCB units.

引用

页码：133 / 140

页数：8

共 33 条

[1]

Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia [J].

Atsuta, Yoshiko ;

Kanda, Junya ;

Takanashi, Minoko ;

Morishima, Yasuo ;

Taniguchi, Shuichi ;

Takahashi, Satoshi ;

Ogawa, Hiroyasu ;

Ohashi, Kazuteru ;

Ohno, Yuju ;

Onishi, Yasushi ;

Aotsuka, Nobuyuki ;

Nagamura-Inoue, Tokiko ;

Kato, Koji ;

Kanda, Yoshinobu .

HAEMATOLOGICA, 2013, 98 (05) :814-822

[2]

How I treat: the selection and acquisition of unrelated cord blood grafts [J].

Barker, Juliet N. ;

Byam, Courtney ;

Scaradavou, Andromachi .

BLOOD, 2011, 117 (08) :2332-2339

[3]

Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies [J].

Barker, Juliet N. ;

Scaradavou, Andromachi ;

Stevens, Cladd E. .

BLOOD, 2010, 115 (09) :1843-1849

[4]

Probability of finding HLA-mismatched related or unrelated marrow or cord blood donors [J].

Beatty, PG ;

Boucher, KM ;

Mori, M ;

Milford, EL .

HUMAN IMMUNOLOGY, 2000, 61 (08) :834-840

[5]

Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood [J].

Brunstein, Claudio G. ;

Gutman, Jonathan A. ;

Weisdorf, Daniel J. ;

Woolfrey, Ann E. ;

DeFor, Todd E. ;

Gooley, Theodore A. ;

Verneris, Michael R. ;

Appelbaum, Frederick R. ;

Wagner, John E. ;

Delaney, Colleen .

BLOOD, 2010, 116 (22) :4693-4699

[6]

COX DR, 1972, J R STAT SOC B, V34, P187

[7]

Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation [J].

Cutler, Corey ;

Kim, Haesook T. ;

Sun, Lixian ;

Sese, Doreen ;

Glotzbecker, Brett ;

Armand, Philippe ;

Koreth, John ;

Ho, Vincent ;

Alyea, Edwin ;

Ballen, Karen ;

Ritz, Jerome ;

Soiffer, Robert J. ;

Milford, Edgar ;

Antin, Joseph H. .

BLOOD, 2011, 118 (25) :6691-6697

[8]

Cord blood transplantation for haematological malignancies: conditioning regimens, double cord transplant and infectious complications [J].

Delaney, Colleen ;

Gutman, Jonathan A. ;

Appelbaum, Frederick R. .

BRITISH JOURNAL OF HAEMATOLOGY, 2009, 147 (02) :207-216

[9]

Haploidentical, unmanipulated, G-CSF-primed bone marrow transplantation for patients with high-risk hematologic malignancies [J].

Di Bartolomeo, Paolo ;

Santarone, Stella ;

De Angelis, Gottardo ;

Picardi, Alessandra ;

Cudillo, Laura ;

Cerretti, Raffaella ;

Adorno, Gaspare ;

Angelini, Stefano ;

Andreani, Marco ;

De Felice, Lidia ;

Rapanotti, Maria Cristina ;

Sarmati, Loredana ;

Bavaro, Pasqua ;

Papalinetti, Gabriele ;

Di Nicola, Marta ;

Papola, Franco ;

Montanari, Mauro ;

Nagler, Arnon ;

Arcese, William .

BLOOD, 2013, 121 (05) :849-857

[10]

Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study [J].

Eapen, Mary ;

Rubinstein, Pablo ;

Zhang, Mei-Jie ;

Stevens, Cladd ;

Kurtzberg, Joanne ;

Scaradavou, Andromachi ;

Loberiza, Fausto R. ;

Champlin, Richard E. ;

Klein, John P. ;

Horowitz, Mary M. ;

Wagner, John E. .

LANCET, 2007, 369 (9577) :1947-1954

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