Microtubule-binding properties of dynactin p150 expedient for dynein motility

被引：18

作者：

Kobayashi, T ^{[1
]}

Shiroguchi, K ^{[1
]}

Edamatsu, M ^{[1
]}

Toyoshima, YY ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, Tokyo 1538902, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 340卷 / 01期

关键词：

dynein; dynactin; microtubule;

D O I：

10.1016/j.bbrc.2005.11.145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dynactin is a hetero-oligomeric protein complex that has an important role in dynein-based intracellular transport. The expressed N-terminal fragments of dynactin p150 bound to microtubules in the ratio of one to one tubulin dimer, independent from the binding of dynein stalk head. Single molecule observation revealed that these fragments moved around on microtubules by Brownian motion. When the dynein-dynactin complex moves on microtubules, p150 can support dynein to maintain contact with microtubules and does not interfere with the motility of dynein, and thus, the dynein-dynactin complex can efficiently achieve long-distance carriage of the cargo. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：23 / 28

页数：6

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