Current theories on the causes of inflammatory bowel disease

被引：91

作者：

Papadakis, KA

Targan, SR

机构：

[1] Cedars Sinai Med Ctr, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Sch Med, Div Gastroenterol, Los Angeles, CA 90024 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0889-8553(05)70057-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The understanding of the pathogenesis of Crohn's disease and ulcerative colitis has greatly expanded over the last decade. The combination of abnormalities in the immune system, the contribution of nonimmune cells in the intestinal mucosa, a variety of genetic risk determinants, and random environmental factors may all be necessary to induce what clinically presents as inflammatory bowel disease. It is likely that several agents can initiate an immune response that in the intestinal microenvironment and the genetic background of the patient finally leads to pathology.

引用

页码：283 / +

页数：15

共 96 条

[1] Functional diversity of helper T lymphocytes [J].