Elevation of serum soluble E-selectin and VCAM-1 in severe asthma

被引:22
作者
Hamzaoui, A
Ammar, J
El Mekki, F
Borgi, O
Ghrairi, HE
Ben Brahim, M
Hamzaoui, K
机构
[1] Med Univ Tunis, Immunohistol Lab, Tunis 1006, Tunisia
[2] Abderrahmane Mami Hosp, Dept Pediat Resp Dis, Ariana, Tunisia
[3] Med Univ Tunis, Dept Physiol, Tunis 1006, Tunisia
关键词
asthma; inflammation; selectins;
D O I
10.1080/09629350120102361
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Objective: To investigate the significance of circulating adhesion molecules associated with leucocyte-endothelial cell interactions in asthma, serum levels of soluble E (sE)-selectin, soluble P (sP)-selectin, soluble L (sL)-selectin, and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in mild, moderate and severe asthma. Method: Serum levels of sE-selectin, sP-selectin, sL-selectin, and sVCAM-1 were measured in 32 women with asthma and 30 healthy donors using an enzyme-linked immunosorbent assay method. Twenty patients were suffering from severe asthma, and 12 from mild/moderate asthma. Results: Serum sE-selectin and sVCAM-1 levels from patients with asthma were significantly higher than those observed in healthy donors (p < 0.01). The levels of sP-selectin were the same as those of controls. The level of sE-selectin exhibited an important increase in the severe asthmatic patients compared with mild/moderate asthma (p < 0.01). The sVCAM-1 level was increased in severe asthma when compared with healthy controls. There was no correlation between the levels of soluble selectins and the age of the patients. A significant correlation was found between sE-selectin and sVCAM-1 levels. Conclusion: These data indicate that circulating soluble forms of the selectins may have different kinetics during the clinical course of asthma, suggesting that they may reflect different inflammatory pathways in severe asthma. Both sVCAM-1 and sE-selectin may be useful immunological markers for monitoring disease activity in asthma.
引用
收藏
页码:339 / 342
页数:4
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