Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra

被引：72

作者：

Mirault, Tristan

Launay, David

Cuisset, Laurence

Hachulla, Eric

Lambert, Marc

Queyrel, Viviane

Quemeneur, Thomas

Morell-Dubois, Sandrine

Hatron, Pierre-Yves

机构：

[1] Univ Lille 2, Reg Univ Hosp, Natl Ctr Vasc Manifestat Scleroderma, Dept Internal Med, Lille, France

[2] Hosp, Dept Biochem Genet, Paris, France

[3] Inst Cochin Genet Mol, F-75014 Paris, France

来源：

ARTHRITIS AND RHEUMATISM | 2006年 / 54卷 / 05期

关键词：

D O I：

10.1002/art.21807

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Muckle-Wells syndrome (MWS) is a dominantly inherited autoinflammatory disease characterized by rashes, fever, arthralgia, sensorineural deafness, and the possible development of systemic AA amyloidosis. We used anakinra to treat a 22-year-old patient with MWS who had deafness and a high serum level of C-reactive protein (CRP). Following treatment with anakinra, the patient's CRP level normalized, and she recovered from deafness. The fact that this occurrence has never been previously reported strengthens the role of anakinra in MWS but also raises new questions about the physiopathology of such deafness.

引用

页码：1697 / 1700

页数：4

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