Soluble ST2 predicts elevated SBP in the community

被引:38
作者
Ho, Jennifer E. [1 ,2 ,3 ]
Larson, Martin G. [1 ,2 ,4 ]
Ghorbani, Anahita [5 ]
Cheng, Susan [1 ,2 ,6 ]
Vasan, Ramachandran S. [1 ,2 ,7 ]
Wang, Thomas J. [1 ,2 ,5 ,8 ]
Januzzi, James L., Jr. [5 ,7 ]
机构
[1] NHLBI, Framingham Heart Study, Framingham, MA USA
[2] Boston Univ, Sch Med, Framingham, MA USA
[3] Boston Univ, Dept Med, Cardiovasc Med Sect, Boston, MA 02215 USA
[4] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Cardiol Div, Boston, MA USA
[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Div Cardiol, Boston, MA USA
[7] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
[8] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiovascu Res Ctr,Dept Med, Boston, MA 02115 USA
关键词
biological markers; blood pressure; epidemiology; hypertension; immune system; risk factors; FAMILY-MEMBER ST2; HEART-FAILURE; NATRIURETIC PEPTIDE; CARDIAC STRUCTURE; SERUM-LEVELS; MORTALITY; RECEPTOR; IL-33; EXPRESSION; HYPERTENSION;
D O I
10.1097/HJH.0b013e3283611bdf
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background:Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with existing cardiovascular disease. ST2 and its ligand, interleukin-33 (IL-33), are expressed in endothelial cells, and may play an important role in the development of early atherosclerosis and vascular biology. We sought to investigate the association of sST2 and progression of blood pressure (BP), as well as the development of hypertension.Methods:Circulating sST2 concentrations were measured in 1834 participants (mean age 56 years, 57% women) of the community-based Framingham Offspring study. Participants were free of hypertension at baseline. Multivariable linear and logistic regression models were used to evaluate the association of sST2 concentrations and subsequent BP outcomes.Results:Higher sST2 concentrations were associated with incident hypertension over 3 years of follow-up [multivariable-adjusted odds ratio per 1 standard deviation increase in sST2 1.22, 95% confidence interval 1.05-1.42, P=0.01]. Individuals in the upper sST2 quartile had a 2.6mmHg greater increase in SBP compared with those in the lowest quartile (P for trend across quartiles 0.002) and a 1.8mmHg greater increase in pulse pressure (P for trend 0.005). In contrast, sST2 concentrations were not associated with changes in DBP (P=0.27).Conclusion:These findings suggest that sST2 concentrations predict changes in BP physiology typically seen with aging and progressive arterial stiffness. Further studies are needed to elucidate underlying mechanisms by which the ST2/IL-33 pathway may contribute to BP physiology.
引用
收藏
页码:1431 / 1436
页数:6
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