Microbial minimalism: Genome reduction in bacterial pathogens

被引：545

作者：

Moran, NA ^{[1
]}

机构：

[1] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

来源：

CELL | 2002年 / 108卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(02)00665-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts.

引用

页码：583 / 586

页数：4

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