Applications of carbon nanotubes in drug delivery

被引:1703
作者
Bianco, A
Kostarelos, K
Prato, M [1 ]
机构
[1] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy
[2] Inst Biol Mol & Cellulaire, CNRS, UPR 9021, F-67084 Strasbourg, France
[3] Univ London, Sch Pharm, Ctr Drug Delivery Res, London WC1N 1AX, England
关键词
D O I
10.1016/j.cbpa.2005.10.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The development of new and efficient drug delivery systems is of fundamental importance to improve the pharmacological profiles of many classes of therapeutic molecules. Many different types of drug delivery systems are currently available. Within the family of nanomaterials, carbon nanotubes (CNT) have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules. CNT can be functionalised with bioactive peptides, proteins, nucleic acids and drugs, and used to deliver their cargos to cells and organs. Because functionalised CNT display low toxicity and are not immunogenic, such systems hold great potential in the field of nanobiotechnology and nanomedicine.
引用
收藏
页码:674 / 679
页数:6
相关论文
共 44 条
[1]
Drug delivery systems: Entering the mainstream [J].
Allen, TM ;
Cullis, PR .
SCIENCE, 2004, 303 (5665) :1818-1822
[2]
GROWTH, STRUCTURE, AND PROPERTIES OF GRAPHITE WHISKERS [J].
BACON, R .
JOURNAL OF APPLIED PHYSICS, 1960, 31 (02) :283-290
[3]
Carbon nanotubes - the route toward applications [J].
Baughman, RH ;
Zakhidov, AA ;
de Heer, WA .
SCIENCE, 2002, 297 (5582) :787-792
[4]
COBALT-CATALYZED GROWTH OF CARBON NANOTUBES WITH SINGLE-ATOMIC-LAYERWALLS [J].
BETHUNE, DS ;
KIANG, CH ;
DEVRIES, MS ;
GORMAN, G ;
SAVOY, R ;
VAZQUEZ, J ;
BEYERS, R .
NATURE, 1993, 363 (6430) :605-607
[5]
Can carbon nanotubes be considered useful tools for biological applications? [J].
Bianco, A ;
Prato, M .
ADVANCED MATERIALS, 2003, 15 (20) :1765-1768
[6]
Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties [J].
Bianco, A ;
Hoebeke, J ;
Godefroy, S ;
Chaloin, O ;
Pantarotto, D ;
Briand, JP ;
Muller, S ;
Prato, M ;
Partidos, CD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) :58-59
[7]
Biomedical applications of functionalised carbon nanotubes [J].
Bianco, A ;
Kostarelos, K ;
Partidos, CD ;
Prato, M .
CHEMICAL COMMUNICATIONS, 2005, (05) :571-577
[8]
Bianco Alberto, 2004, Expert Opin Drug Deliv, V1, P57, DOI 10.1517/17425247.1.1.57
[9]
Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing [J].
Cai, D ;
Mataraza, JM ;
Qin, ZH ;
Huang, ZP ;
Huang, JY ;
Chiles, TC ;
Carnahan, D ;
Kempa, K ;
Ren, ZF .
NATURE METHODS, 2005, 2 (06) :449-454
[10]
CHAUDHURI A, 2003, CURR MED CHEM, V10, P1185