Hormonal and metabolic responses to electrically induced cycling during epidural anesthesia in humans

被引:36
作者
Kjaer, M
Secher, NH
Bangsbo, J
Perko, G
Horn, A
Mohr, T
Galbo, H
机构
[1] RIGSHOSP,COPENHAGEN MUSCLE RES CTR,DK-2100 COPENHAGEN,DENMARK
[2] RIGSHOSP,DEPT INTERNAL MED TTA,DK-2100 COPENHAGEN,DENMARK
[3] RIGSHOSP,DEPT ANAESTHESIA,DK-2100 COPENHAGEN,DENMARK
[4] AUGUST KROGH INST,DEPT HUMAN PHYSIOL,COPENHAGEN,DENMARK
[5] BISPEBJERG HOSP,DEPT REUMATOL H,COPENHAGEN,DENMARK
关键词
norepinephrine; epinephrine; renin; growth hormone; adrenocorticotropic hormone; insulin; hepatic glucose production; muscle glycogen; lactate; creatine phosphate; free fatty acids;
D O I
10.1152/jappl.1996.80.6.2156
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Hormonal and metabolic responses to electrically induced dynamic exercise were investigated in eight healthy young men with afferent neural influence from the legs blocked by epidural anesthesia (25 ml of 2% lidocaine) at L(3)-L(4). This caused cutaneous sensory anesthesia below T-8-T-9 and complete paralysis of the legs. Cycling increased oxygen uptake to 1.90 +/- 0.13 (SE) l/min, and fatigue developed after 22.7 +/- 2.7 min. Compared with voluntary exercise at the same oxygen uptake and heart rate, concentrations of blood and muscle lactate (musculus vastus lateralis) as well as plasma potassium increased more while muscle glycogen decreased more during electrically induced exercise. Hepatic glucose production always rose during exercise. However, during involuntary exercise with sensory blockade, it did not match the rise in peripheral glucose uptake and plasma glucose decreased (P < 0.05). Plasma glycerol increased less in electrically induced vs. voluntary exercise, and free fatty acids and beta-hydroxybutyrate decreased only during electrically induced exercise. Epinephrine, growth hormone, adrenocorticotropic hormone, and cortisol levels were higher during involuntary vs. voluntary exercise (P < 0.05). In conclusion, neural and humoral mechanisms exert redundant control with regard to responses of catecholamines and pituitary hormones (growth hormone and adrenocorticotropic hormone). In contrast, neural input from motor centers and feedback. from working muscle are important for glucose production and lipolysis during exercise in humans. Humoral feedback is apparently not sufficient to trigger normal mobilization of extramuscular fuel stores.
引用
收藏
页码:2156 / 2162
页数:7
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