Determination of acyclovir in human plasma by high-performance liquid chromatography

被引：57

作者：

Boulieu, R ^{[1
]}

Gallant, C ^{[1
]}

Silberstein, N ^{[1
]}

机构：

[1] HOP NEUROCARDIOL,SERV PHARMACEUT,F-69394 LYON 03,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 693卷 / 01期

关键词：

acyclovir;

D O I：

10.1016/S0378-4347(97)00037-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations, The quantification limit was 0.1 mg/l for a plasma volume of 500 mu l and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.

引用

页码：233 / 236

页数：4

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