Computational analysis suggests beta-defensins are processed to mature peptides by signal peptidase

被引：21

作者：

Beckloff, Nicholas ^{[1
]}

Diamond, Gill ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Dent Sch, Dept Oral Biol, Newark, NJ 07103 USA

来源：

PROTEIN AND PEPTIDE LETTERS | 2008年 / 15卷 / 05期

关键词：

antimicrobial peptide; innate immunity; host defense; signal sequence;

D O I：

10.2174/092986608784567618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.

引用

页码：536 / 540

页数：5

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