Scrapie infectivity in hamster blood is not associated with platelets

被引：68

作者：

Holada, K

Vostal, JG

Theisen, PW

MacAuley, C

Gregori, L

Rohwer, RG

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Lab Cellular Hematol, Bethesda, MD 20892 USA

[2] Dept Vet Affairs Med Ctr, Mol Neurovirol Lab, Baltimore, MD 21201 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 09期

关键词：

D O I：

10.1128/JVI.76.9.4649-4650.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The infectivity of hamster scrapie strain 263K was measured in platelets isolated from blood pooled from six hamsters with clinical scrapie. The total number of infectious doses present in the blood pool was 220, out of which only 3.5 infectious doses were associated with platelets. A larger proportion of the total infectivity was recovered from the mononuclear leukocyte fraction. This result indicates that platelets are not the source of blood-borne infectivity in transmissible spongiform encephalopathy-infected hamsters.

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页码：4649 / 4650

页数：2

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