R-R interval variation in Parkinson's disease and multiple system atrophy

被引：15

作者：

Gurevich, TY ^{[1
]}

Groozman, GB ^{[1
]}

Giladi, N ^{[1
]}

Drory, VE ^{[1
]}

Hausdorff, JM ^{[1
]}

Korczyn, AD ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Neurol, Tel Aviv Sourasky Med Ctr, IL-69978 Tel Aviv, Israel

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2004年 / 109卷 / 04期

关键词：

Parkinson's disease; multiple system atrophy; heart rate variability; autonomic function;

D O I：

10.1111/j.1600-0404.2004.00226.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective - To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). Background - RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. Methods - RRIV at rest and after 120 s of deep breathing was assessed blindly to clinical diagnosis in 22 PD and 20 MSA patients. The results were compared with data from 23 age-matched healthy subjects. Results - RRIV at rest was 7.1 +/- 2.7% in PD and 9.7 +/- 7.2% in MSA, increasing after deep breathing to 11.2 +/- 6.3 and 12.3 +/- 6.6% correspondingly. The frequency of the RRIV abnormalities in the PD group (4/22, 18.2%) and MSA (6/20, 30%) were higher than among controls (P < 0.004). Conclusions - RRIV, either at rest or after deep breathing, may be abnormal both in PD and MSA, but does not distinguish between these disorders.

引用

页码：276 / 279

页数：4

共 12 条

[1] Sympathetic skin response and R-R interval variability in multiple system atrophy and idiopathic Parkinson's disease [J].