The role of transporters in drug interactions

被引：149

作者：

Endres, CJ ^{[1
]}

Hsiao, P ^{[1
]}

Chung, FS ^{[1
]}

Unadkat, JD ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2006年 / 27卷 / 05期

关键词：

drug transporters; drug interactions; in vitro-in vivo correlation;

D O I：

10.1016/j.ejps.2005.11.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro-in vivo correlation is important for predicting future transporter-based drug interactions. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：501 / 517

页数：17

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