Statin discontinuation: an underestimated risk?

被引：45

作者：

Tziomalos, Konstantinos ^{[1
]}

Athyros, Vasilios G. ^{[2
]}

Mikhailidis, Dimitri P. ^{[1
]}

机构：

[1] UCL, Univ Coll, Sch Med, Dept Clin Biochem,Vasc Prevent Clin, London NW3 2QG, England

[2] Aristotle Univ Thessaloniki, Propedeut Dept Internal Med 2, Hippokration Hosp, GR-54006 Thessaloniki, Greece

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 2008年 / 24卷 / 11期

关键词：

Adherence; Coronary heart disease; Myocardial infarction; Vascular risk;

D O I：

10.1185/03007990802469102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statin treatment is essential for the prevention of vascular disease. Despite the established benefits of statins, discontinuation of these agents is frequent. Whether statin discontinuation leads to adverse outcomes is still debated and the most convincing evidence is mainly restricted to patients who experienced an acute vascular event. It is important to establish if this phenomenon extends to other populations, like those without vascular disease but with a high calculated risk. Overall, it appears that even a brief discontinuation of statins might be harmful. Therefore, statin treatment should not be interrupted except if there is a very good reason. Moreover, patients should be instructed as to why they must adhere to their medication. Adherence should be monitored regularly.

引用

页码：3059 / 3062

页数：4

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