Existing and Emerging Technologies for Tumor Genomic Profiling

被引：108

作者：

MacConaill, Laura E. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 15期

基金：

美国国家卫生研究院;

关键词：

CELL LUNG-CANCER; WHOLE-GENOME; SOMATIC MUTATIONS; DRIVER MUTATIONS; SINGLE-MOLECULE; GENE-MUTATIONS; DNA-BINDING; RNA-SEQ; SEQUENCE; GEFITINIB;

D O I：

10.1200/JCO.2012.46.5948

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer genomics and tumor biology. In parallel, information gleaned from these studies on driver cancer gene alterations-mutations, copy number alterations, translocations, and/or chromosomal rearrangements-can be leveraged, in principle, to develop a cohesive framework for individualized cancer treatment. These possibilities have been enabled, to a large degree, by revolutionary advances in genomic technologies that facilitate systematic profiling for hallmark cancer genetic alterations at increasingly fine resolutions. Ongoing innovations in existing genomics technologies, as well as the many emerging technologies, will likely continue to advance translational cancer genomics and precision cancer medicine.

引用

页码：1815 / 1824

页数：10

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