Mannitol: Molecule magnifique or a case of radical misinterpretation? Commentary

被引：24

作者：

Gillbe, CE ^{[1
]}

Sage, FJ ^{[1
]}

Gutteridge, JMC ^{[1
]}

机构：

[1] ROYAL BROMPTON HOSP, DEPT ANAESTHESIA & ADULT INTENS CARE, LONDON SW3 6NP, ENGLAND

来源：

FREE RADICAL RESEARCH | 1996年 / 24卷 / 01期

关键词：

D O I：

10.3109/10715769609087994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species are constantly formed in biological systems. When production exceeds antioxidant protection, oxidative stress leading to molecular damage occurs. The most reactive ROS in biological systems is the hydroxyl radical which damages adjacent molecules at diffusion controlled rates. The possibility of preventing such chemistry inside cells with therapeutic doses of mannitol at present seem remote.

引用

页码：1 / 7

页数：7

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