The effect of APOE on dementia is not through atherosclerosis:: The Rotterdam Study

被引：38

作者：

Slooter, AJC

Cruts, M

Ott, A

Bots, ML

Witteman, JCM

Hofman, A

Van Broeckhoven, C

Breteler, MMB

van Duijn, CM

机构：

[1] Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[2] Univ Utrecht, Dept Neurol, NL-3584 CX Utrecht, Netherlands

[3] Univ Utrecht, Julius Ctr Patient Oriented Res, NL-3584 CX Utrecht, Netherlands

[4] Univ Antwerp VIB, Neurogenet Lab, Born Bunge Fdn,Dept Biochem, Antwerp, Belgium

来源：

NEUROLOGY | 1999年 / 53卷 / 07期

关键词：

APOE; dementia; atherosclerosis; the Rotterdam Study;

D O I：

10.1212/WNL.53.7.1593

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-epsilon 4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.

引用

页码：1593 / 1595

页数：3

共 10 条

[1]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[2] CEREBRAL WHITE MATTER LESIONS AND ATHEROSCLEROSIS IN THE ROTTERDAM STUDY [J].

BOTS, ML ;

VANSWIETEN, JC ;

BRETELER, MMB ;

DEJONG, PTVM ;

VANGIJN, J ;

HOFMAN, A ;

GROBBEE, DE .

LANCET, 1993, 341 (8855) :1232-1237

[3]

Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.1997.03550160069041

[4] APOLIPOPROTEIN-E POLYMORPHISMS AFFECT ATHEROSCLEROSIS IN YOUNG MALES [J].

HIXSON, JE .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1237-1244

[5] Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study [J].

Hofman, A ;

Ott, A ;

Breteler, MMB ;

Bots, ML ;

Slooter, AJC ;

vanHarskamp, F ;

vanDuijn, CN ;

Van Broeckhoven, C ;

Grobbee, DE .

LANCET, 1997, 349 (9046) :151-154

[6] DETERMINANTS OF DISEASE AND DISABILITY IN THE ELDERLY - THE ROTTERDAM ELDERLY STUDY [J].

HOFMAN, A ;

GROBBEE, DE ;

DEJONG, PTVM ;

VANDENOUWELAND, FA .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1991, 7 (04) :403-422

[7]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[8]

Ott A, 1998, AM J EPIDEMIOL, V147, P574

[9] VASCULAR DEMENTIA - DIAGNOSTIC-CRITERIA FOR RESEARCH STUDIES - REPORT OF THE NINDS-AIREN INTERNATIONAL WORKSHOP [J].

ROMAN, GC ;

TATEMICHI, TK ;

ERKINJUNTTI, T ;

CUMMINGS, JL ;

MASDEU, JC ;

GARCIA, JH ;

AMADUCCI, L ;

ORGOGOZO, JM ;

BRUN, A ;

HOFMAN, A ;

MOODY, DM ;

OBRIEN, MD ;

YAMAGUCHI, T ;

GRAFMAN, J ;

DRAYER, BP ;

BENNETT, DA ;

FISHER, M ;

OGATA, J ;

KOKMEN, E ;

BERMEJO, F ;

WOLF, PA ;

GORELICK, PB ;

BICK, KL ;

PAJEAU, AK ;

BELL, MA ;

DECARLI, C ;

CULEBRAS, A ;

KORCZYN, AD ;

BOGOUSSLAVSKY, J ;

HARTMANN, A ;

SCHEINBERG, P .

NEUROLOGY, 1993, 43 (02) :250-260

[10] Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam study [J].

Slooter, AJC ;

Cruts, M ;

Kalmijn, S ;

Hofman, A ;

Breteler, MMB ;

Van Broeckhoven, C ;

van Duijn, CM .

ARCHIVES OF NEUROLOGY, 1998, 55 (07) :964-968

← 1 →