Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats

被引：16

作者：

Li, He ^{[1
,2
]}

Ma, Xiao-qing ^{[1
]}

Ye, Fan ^{[1
]}

Zhang, Jing ^{[1
]}

Zhou, Xin ^{[1
]}

Wang, Zhi-hong ^{[1
]}

Li, Yu-ming ^{[1
]}

Zhang, Guo-yuan ^{[2
]}

机构：

[1] Chinese Peoples Armed Police Force, Inst Cardiovasc Dis, Coll Med, Cardiovasc Div,Dept Geriatr Med,Pingjin Hosp, Tianjin 300162, Peoples R China

[2] Changzheng Hosp, Div Cardiovasc, Shanghai 200003, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2009年 / 10卷 / 03期

关键词：

Norepinephrine transporter (NET); beta(1)-adrenergic receptor (beta(1)-AR); Cardiac sympathetic ganglion; Aging; HEART-FAILURE; MESSENGER-RNA; TRANSCRIPTION FACTOR; PROTEIN EXPRESSION; LOCUS-COERULEUS; DOWN-REGULATION; INNERVATION; SYSTEM; BRAIN; ABNORMALITIES;

D O I：

10.1631/jzus.B0820213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the beta-adrenergic receptor (beta-AR). In the present study, we investigated NET and beta 1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and beta(1)-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.

引用

页码：203 / 210

页数：8

共 46 条

[1]

Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure [J].