Development and applications of transgenesis in the yellow fever mosquito, Aedes aegypti

被引:40
作者
Adelman, ZN [1 ]
Jasinskiene, N [1 ]
James, AA [1 ]
机构
[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
关键词
Aedes aegypti; mosquito transformations; genetic control of diseases; transposable elements;
D O I
10.1016/S0166-6851(02)00028-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transgenesis technology has been developed for the yellow fever mosquito, Aedes aegypti. Successful integration of exogenous DNA into the germline of this mosquito has been achieved with the class II transposable elements, Hermes, mariner and piggyBac. A number of marker genes. including the cinnabar(+) gene of Drosophila melanogaster. and fluorescent protein genes, can be used to monitor the insertion of these elements. The availability of multiple elements and marker genes provides a powerful set of tools to investigate basic biological properties of this vector insect. as well as the materials for developing novel, genetics-based, control strategies for the transmission of disease. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 10
页数:10
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