Brown adipose tissue: the molecular mechanism of its formation

被引：21

作者：

Wolf, George ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

NUTRITION REVIEWS | 2009年 / 67卷 / 03期

关键词：

adipocytes; brown adipose tissue; PRDM16; thermogenesis; uncoupling protein; white adipose tissue; UNCOUPLING PROTEIN; ADIPOCYTES; PRDM16;

D O I：

10.1111/j.1753-4887.2009.00184.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The function of brown adipose tissue (BAT) is to oxidize fat and to dissipate the energy produced as heat, providing a source of heat to the organism. Preadipocytes are stimulated by expression of the PRDM16 gene to differentiate into BAT cells. The PRDM16 protein is greatly enriched in BAT and causes increased expression of mitochondrial genes and greater density of mitochondria. It increases expression of the uncoupling factor UCP1 and thereby causes a large stimulation of uncoupled respiration with resultant heat production, enhanced by cAMP. Recent evidence strongly supports the idea that the PRDM16 gene determines BAT identity.

引用

页码：167 / 171

页数：5

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