Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass

被引：152

作者：

Nielsen, Anders Rinnov ^{[1
,2
]}

Hojman, Pernille ^{[1
,3
]}

Erikstrup, Christian ^{[1
,2
]}

Fischer, Christian Philip ^{[1
,2
]}

Plomgaard, Peter ^{[1
,2
]}

Mounier, Remi ^{[1
,2
]}

Mortensen, Ole Hartvig ^{[1
,2
]}

Broholm, Christa ^{[1
,2
]}

Taudorf, Sarah ^{[1
,2
]}

Krogh-Madsen, Rikke ^{[1
,2
]}

Lindegaard, Birgitte ^{[1
,2
]}

Petersen, Anne Marie Winther ^{[1
,2
]}

Gehl, Julie ^{[3
]}

Pedersen, Bente Klarlund ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Ctr Inflammat & Metab, Dept Infect Dis, Rigshosp, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Herlev Hosp, Dept Oncol, DK-2730 Herlev, Denmark

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2008年 / 93卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1210/jc.2007-2561

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass. (J Clin Endocrinol Metab 93: 4486-4493, 2008)

引用

页码：4486 / 4493

页数：8

共 21 条

[1] Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models:: evidence for direct IL-15 action on adipose tissue [J].