Sex differences of oxidative stress markers in young healthy subjects are marker-specific in plasma but not in saliva

被引:19
作者
Tothova, L'ubomira [1 ]
Ostatnikova, Daniela [2 ]
Sebekova, Katarina [1 ]
Celec, Peter [1 ,3 ,4 ]
Hodosy, Julius [1 ,2 ]
机构
[1] Comenius Univ, Fac Med Bratislava, Inst Mol Biomed, Bratislava 81108, Slovakia
[2] Comenius Univ, Fac Med Bratislava, Inst Physiol, Bratislava 81108, Slovakia
[3] Comenius Univ, Fac Med Bratislava, Inst Pathophysiol, Bratislava 81108, Slovakia
[4] Comenius Univ, Fac Nat Sci, Dept Mol Biol, Bratislava 81108, Slovakia
关键词
Sex differences; biochemical markers; carbonyl stress; sex hormones; saliva; ACID REACTING SUBSTANCES; GENDER-DIFFERENCES; ANTIOXIDANT CAPACITY; CARDIOVASCULAR-DISEASE; WOMEN; GLYCATION; PRODUCTS; EXERCISE; RATS; MEN;
D O I
10.3109/03014460.2012.754495
中图分类号
Q98 [人类学];
学科分类号
070906 [古生物学及地层学(含古人类学)];
摘要
Background: Several studies showed there are sex differences in oxidative stress. An observational study analysing oxidative stress markers in young healthy men and women is lacking. Moreover, it is unclear whether the differences are related to sex hormones. Aim: The primary goal was to analyse differences in oxidative stress markers with regard to sex in plasma of young healthy subjects and whether differences are related to sex hormones. The secondary study compared oxidative stress markers in plasma with salivary samples. Methods: Plasma and saliva samples were analysed from 158 young healthy probands. Established spectro-photometric/fluorometric methods were used to quantify oxidative stress markers. Sex hormones were measured using ELISA kits. Results: In plasma, malondialdehyde and advanced glycation end products were significantly higher in women. Advanced oxidation protein products and the ferric reducing ability of plasma were higher in men. Sex hormones were not associated with oxidative stress markers. In saliva, analysed markers of antioxidant status were higher in men, but no sex differences were found in other markers. Conclusion: Observed parameters showed marker-specific sex differences in plasma, but these differences were not related to sex hormones. Plasma and saliva concentrations of biomarkers did not correlate, reflecting oral but not systemic conditions.
引用
收藏
页码:175 / 180
页数:6
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