Metabolomics plafforms for genome wide association studies-linking the genome to the metabolome

被引：81

作者：

Adamski, Jerzy ^{[1
,2
,3
]}

Suhre, Karsten ^{[4
,5
]}

机构：

[1] German Res Ctr Environm Hlth, Inst Expt Genet, Genome Anal Ctr, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Life & Food Sci Ctr Weihenstephan, Inst Expt Genet, D-85354 Freising Weihenstephan, Germany

[3] German Ctr Diabet Res, D-85764 Neuherberg, Germany

[4] German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany

[5] Weill Cornell Med Coll, Dept Physiol & Biophys, Educ City, Qatar

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2013年 / 24卷 / 01期

关键词：

HDL-CHOLESTEROL CONCENTRATIONS; FLIGHT MASS-SPECTROMETRY; GAS-CHROMATOGRAPHY; GENETIC-VARIATION; ACID INTAKE; LOCI; SERUM; INTERACTS; PLATFORM;

D O I：

10.1016/j.copbio.2012.10.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWAS) reveal links between genetic variance and predisposition to disease. With the advent of modern 'omics-technologies', GWAS can now identify the genetic factors that influence intermediate traits on pathways to disease, such as blood concentrations of carbohydrates, lipids, amino acids, and secondary metabolites, hormones and signal molecules. At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field.

引用

页码：39 / 47

页数：9

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