The balance of Th1/Th2 cytokines in rheumatoid arthritis

被引：241

作者：

Schulze-Koops, H

Kalden, JK

机构：

[1] Nikolaus Fiebiger Ctr Mol Med, Clin Res Grp 3, D-91054 Erlangen, Germany

[2] Nikolaus Fiebiger Ctr Mol Med, Dept Internal Med 3, D-91054 Erlangen, Germany

[3] Nikolaus Fiebiger Ctr Mol Med, Inst Clin Immunol, D-91054 Erlangen, Germany

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2001年 / 15卷 / 05期

关键词：

rheumatoid arthritis; Th1/Th2; autoimmunity; cytokines; pathogenesis; treatment;

D O I：

10.1053/berh.2001.0187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been suggested that rheumatoid inflammation is mediated by activated pro-inflammatory T helper type 1 cells. In contrast, immunomodulatory T helper type 2 cells and their cytokines, in particular interleukin-4, are rarely found. This chapter reviews the concept of the Th1/Th2 dichotomy and summarizes the functions of the signature cytokines of the T helper subsets. We discuss current knowledge of the immunopathogenesis of rheumatoid arthritis and its related animal model, collagen induced arthritis, with regard to the Th1/Th2 paradigm. The accumulating evidence for a T helper type 1 driven inflammation and the implications for future therapy are delineated.

引用

页码：677 / 691

页数：15

共 59 条

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