Microglia and neuroinflammation: a pathological perspective

被引：797

作者：

Streit, Wolfgang J. ^{[1
]}

Mrak, Robert E. ^{[2
]}

Griffin, W. Sue T. ^{[3
,4
]}

机构：

[1] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA

[2] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA

[4] GRECC CAVHS, Little Rock, AR 72205 USA

来源：

JOURNAL OF NEUROINFLAMMATION | 2004年 / 1卷 / 1期

关键词：

Human Immunodeficiency Virus; Amyotrophic Lateral Sclerosis; Microglial Activation; Rabies; Prion Disease;

D O I：

10.1186/1742-2094-1-14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. Their role in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses. Specific reference is made also to their involvement in Alzheimer's disease where microglial cell activation is thought to be critically important in the neurodegenerative process.

引用

页数：4

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