Structural analysis of secondary ions by post-source decay in time-of-flight secondary ion mass spectrometry

被引：28

作者：

Touboul, D ^{[1
]}

Brunelle, A ^{[1
]}

Laprévote, O ^{[1
]}

机构：

[1] CNRS, UPR 2301, Ins Chim Subst Nat, Lab Spectromet Masse, F-91198 Gif Sur Yvette, France

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2006年 / 20卷 / 04期

关键词：

D O I：

10.1002/rcm.2362

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tandem mass spectrometry measurements have been achieved using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and a post source decay (PSD)-like method. The performance of the method has been demonstrated on model molecules with well-known fragmentation pathways. Several lipids have been fragmented including the phosphocholine ion, phosphatidylcholines, cholesterol and vitamin E. Pure samples were analyzed, and the results compared with those obtained with the same compounds on a quadrupole-TOF hybrid mass spectrometer. Then, the structures of some lipids which are currently observed in the TOF-SIMS imaging of mammalian tissue sections were verified. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：703 / 709

页数：7

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