Alkylbenzyl ethers of hydroquinones as monoamine oxidase B inhibitors

被引：5

作者：

Arvanitis, AG

Scholfield, EL

Grigoriadis, D

Heytler, PG

Bowdle, J

Chorvat, RJ

机构：

[1] DuPont Merck Pharmaceutical Company, Wilmington

[2] Neurocrine Biosciences, Inc., San Diego, CA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 02期

关键词：

D O I：

10.1016/0960-894X(95)00561-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of alkylbenzylethers of substituted hydroquinone analogs of 4-(3-chlorophenyl methyloxy)-phenoxybutyronitrile I, and alcohol II were synthesized as monoamine oxidase (MAO) inhibitors. Incorporation of electron-withdrawing groups on the hydroquinone afforded compounds with higher levels of activity and selectivity than I or II for MAO B inhibition.

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页码：115 / 120

页数：6

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