Initial ethanol exposure results in decreased heart rate variability in ethanol-naive rhesus monkeys

Ethanol's effects on heart rate variability may contribute to the increased cardiac disease and mortality observed far alcoholics. We assessed cardiac response to ethanol in seven previously ethanol-naive monkeys given a standard dose of ethanol, or saline. Ethanol exposure reduced cardiac signal complexity [mean +/- S.D, (ethanol: Hurst parameter = 0.39 +/- 0.02; saline: Hurst parameter = 0.32 +/- 0.06)] and increased the spectral exponent (ethanol: beta = 1.36 +/- 0.35; saline: beta = 1.12 +/- 0.35) when compared to saline, while heart rate itself was unaffected (saline: interbeat interval = 303.57 +/- 24.57; ethanol: interbeat interval = 308.14 +/- 20.45). Taken together with data that show autonomic disregulation in alcoholics, these findings provide further evidence of deleterious ethanol effects on cardiac signal dynamics. (C) 2001 Published by Elsevier Science B.V.