Inhibition of Mayaro virus replication by prostaglandin A1 in Vero cells

被引：14

作者：

Burlandy, FM ^{[1
]}

Rebello, MA ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Microbiol Prof Paulo de Goes, BR-21941590 Rio De Janeiro, Brazil

来源：

INTERVIROLOGY | 2001年 / 44卷 / 06期

关键词：

prostaglandin A1; heat shock proteins; Mayaro virus replication; Vero cells; actinomycin D;

D O I：

10.1159/000050069

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Prostaglandins exhibit antiviral activity against a wide variety of RNA and DNA viruses. In the present report, we describe the effect of cyclopentenone prostaglandin A(1) (PGA(1)) on Mayaro virus replication in Vero cells. Virus yield was significantly reduced at nontoxic concentrations which did not suppress DNA, RNA or protein synthesis in uninfected or infected cells. Antiviral action decreased if PGA(1) was added at later times after infection. In Mayaro virus-infected cells, PGA(1) inhibited the synthesis of virus proteins. This effect is accompanied by the induction of heat shock proteins (HSPs). Actinomycin D treatment not only inhibited the induction of HSPs but also partially prevented PGA1 antiviral activity. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：344 / 349

页数：6

共 24 条

[1] SELECTIVE-INHIBITION OF VIRUS PROTEIN-SYNTHESIS BY PROSTAGLANDIN A(1) - A TRANSLATIONAL BLOCK ASSOCIATED WITH HSP70 SYNTHESIS [J].