Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice

被引：75

作者：

Custodio, Charllyany Sabino ^{[1
,2
]}

Ferreira Mello, Bruna Stefania ^{[1
,2
]}

Cordeiro, Rafaela Carneiro ^{[2
]}

Ramos de Araujo, Fernanda Yvelize ^{[2
]}

Chaves, Joao Henrique ^{[2
]}

Mendes Vasconcelos, Silvania Maria ^{[2
]}

Nobre Junior, Helio Vitoriano ^{[1
]}

Florenco de Sousa, Francisca Clea ^{[2
]}

Vale, Mariana Lima ^{[3
]}

Carvalho, Andre Ferrer ^{[4
]}

Macedo, Danielle Silveira ^{[2
,4
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Pathol, Postgrad Program Med Microbiol, BR-60431270 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, Neuropharmacol Lab, BR-60431270 Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, Lab Inflammat & Canc Pharmacol, BR-60431270 Fortaleza, Ceara, Brazil

[4] Univ Fed Ceara, Fac Med, Psychiat Res Grp, BR-60431270 Fortaleza, Ceara, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2013年 / 713卷 / 1-3期

关键词：

Lipopolysaccharide; Sickness behavior; Depressive-like behavior; Neuroinflammation; Nitric oxide; OXIDE SYNTHASE CONTRIBUTES; MAJOR DEPRESSIVE DISORDER; ACOUSTIC STARTLE; SICKNESS BEHAVIOR; MOOD DISORDERS; TNF-ALPHA; RATS; CYTOKINES; STRESS; ENDOTOXIN;

D O I：

10.1016/j.ejphar.2013.04.040

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) administration to mice on parameters, such as PPI, depressive- and anxiety-like behaviors, working memory, locomotor activity and motor coordination, 1.5 and 24 h post-LPS administration. IL-1 beta and TNF alpha in the blood and brain as well as brain nitrite levels were evaluated in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). An overall hypolocomotion was observed 1.5 h post-LPS, along with depressive-like behaviors and deficits in working memory. Increments in IL-1 beta content in plasma and PFC, TNF alpha in plasma and decreases in nitrite levels in the ST and PFC were also verified. Twenty-four hours post-LPS treatment, depressive-like behaviors and working memory deficits persisted, while PPI levels significantly reduced along with increases in IL-1 beta content in the PFC and a decrease in nitrite levels in the HC, ST and PFC. Our data demonstrate that a delayed increase (i.e., 24 h post-LPS) in PPI levels ensue, which may be useful behavioral parameter for LPS-induced depression. A decrease in nitrergic neurotransmission was associated with these behavioral findings. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：31 / 38

页数：8

共 54 条

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