Study of osteoblast differentiation and proliferation on the surface of binary bioactive gel-glasses

被引：2

作者：

Bielby, RC

Saravanapavan, P

Polak, JM

Hench, LL

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Fac Med, Tissue Engn Ctr, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Mat, Tissue Engn Ctr, London, England

来源：

BIOCERAMICS 14 | 2002年 / 218-2卷

关键词：

osteoblasts; proliferation; SiO2-CaO gel-glasses;

D O I：

10.4028/www.scientific.net/KEM.218-220.269

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Previous studies have shown that glasses in the binary system CaO-SiO2 containing 30 mol% CaO, prepared by means of a sol-gel route are reported to be bioactive. However, its effects on cellular metabolic activity have never been explored. The objective of this study was to investigate the behaviour of osteoblasts on the surface of S70C30 glass substrates. Previous work found that melt-derived 45S5 Bioglass(R) substrates supported enhanced osteoblast function and gene expression compared to standard tissue culture plastics. This study supports the hypothesis that P2O5 free binary S70C30 gel-glass provides a favourable environment for osteoblast proliferation and function.

引用

页码：269 / 272

页数：4

共 12 条

[1] Bioactive materials [J].

Cao, WP ;

Hench, LL .

CERAMICS INTERNATIONAL, 1996, 22 (06) :493-507

[2]

Hench L.L., 1971, Journal of Biomedical Materials Research Symposium, V36, P117, DOI DOI 10.1002/JBM.820050611

[3]

Hench LL., 1996, Life Chemistry Reports, V13, P187

[4] BIOACTIVE GLASS-CERAMICS - PROPERTIES AND APPLICATIONS [J].

KOKUBO, T .

BIOMATERIALS, 1991, 12 (02) :155-163

[5] AN INVESTIGATION OF BIOACTIVE GLASS POWDERS BY SOL-GEL PROCESSING [J].

LI, R ;

CLARK, AE ;

HENCH, LL .

JOURNAL OF APPLIED BIOMATERIALS, 1991, 2 (04) :231-239

[6] Mineral evolution of bone [J].

Ravaglioli, A ;

Krajewski, A ;

Celotti, GC ;

Piancastelli, A ;

Bacchini, B ;

Montanari, L ;

Zama, G ;

Piombi, L .

BIOMATERIALS, 1996, 17 (06) :617-622

[7]

Saravanapavan P, 2001, J BIOMED MATER RES, V54, P608, DOI 10.1002/1097-4636(20010315)54:4<608::AID-JBM180>3.0.CO

[8]

2-U

[9]

SARAVANAPAVAN P, 2000, P 13 INT S CER MED B, P608

[10] Bioglass ®45S5 stimulates osteoblast turnover and enhances bone formation in vitro:: Implications and applications for bone tissue engineering [J].

Xynos, ID ;

Hukkanen, MVJ ;

Batten, JJ ;

Buttery, LD ;

Hench, LL ;

Polak, JM .

CALCIFIED TISSUE INTERNATIONAL, 2000, 67 (04) :321-329

← 1 2 →