Molecules in the signaling pathway activated by gangliosides can be targets of therapeutics for malignant melanomas

被引：17

作者：

Furukawa, Koichi ^{[1
]}

Hamamura, Kazunori ^{[1
]}

Nakashima, Hideyuki ^{[1
]}

Furukawa, Keiko ^{[1
,2
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 4660065, Japan

[2] Chubu Univ, Coll Life & Hlth Sci, Dept Biomed Sci, Kasugai, Aichi 487, Japan

来源：

PROTEOMICS | 2008年 / 8卷 / 16期

关键词：

glycosphingolipid; integrin; lipid raft; signal; tumor-associated antigen;

D O I：

10.1002/pmic.200800228

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

There have been a number of studies on tumor-specific glycolipid antigens. In particular, neuroectoderm-derived cancers express characteristic ganglioside antigens, some of them have been used as tumor markers and/or target of immunotherapy. Molecules in the signaling pathway activated by gangliosides have been analyzed. Here, we reported results on the functions of molecules involved in the signaling pathway to enhance malignant properties of human melanomas under GD3 expression, and emphasized that those molecules including tumor-associated antigens can be targets of therapeutics for malignant melanomas.

引用

页码：3312 / 3316

页数：5

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