Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice

被引：16

作者：

Baz, Mariana

Abed, Yacine

Nehme, Benjamin

Boivin, Guy ^{[1
]}

机构：

[1] CHUL, CHUQ, Res Ctr Infect Dis, Ste Foy, PQ G1V 4G2, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期

关键词：

A-315675; INFECTION;

D O I：

10.1128/AAC.01276-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y mutant when therapy was started 4 h before or even 48 h after infection.

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收藏

页码：791 / 793

页数：3

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