Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

被引：7

作者：

Hayashi, Y ^{[1
]}

Sato, Y ^{[1
]}

Katada, J ^{[1
]}

Takiguchi, Y ^{[1
]}

Ojima, I ^{[1
]}

Uno, I ^{[1
]}

机构：

[1] SUNY STONY BROOK, DEPT CHEM, STONY BROOK, NY 11794 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00224-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl-Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti-thrombotic agent during extracorporeal circulation. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1351 / 1356

页数：6

共 20 条

[1] PLATELETS AND EXTRACORPOREAL-CIRCULATION [J].

ADDONIZIO, VP ;

COLMAN, RW .

BIOMATERIALS, 1982, 3 (01) :9-15

[2] INCIDENCE AND EFFECTS OF PARTICULATE AGGREGATION AND MICROEMBOLISM IN PUMP-OXYGENATOR SYSTEMS [J].

ASHMORE, PG ;

SVITEK, V ;

AMBROSE, P .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1968, 55 (05) :691-+

[3]

CARTEAUX JP, 1993, THROMB HAEMOSTASIS, V70, P817

[4]

COLLEN D, 1994, THROMB HAEMOSTASIS, V71, P95

[5]

Cook Nigel S., 1994, Drugs of the Future, V19, P135

[6]

COOK NS, 1993, THROMB HAEMOSTASIS, V70, P838

[7]

FOK KF, 1991, INT J PEPT PROT RES, V38, P124

[8]

FUJII N, 1987, CHEM PHARM BULL, V35, P3880

[9] FIBRINOGEN RECEPTORS IN PLATELET-ADHESION TO SURFACES OF EXTRACORPOREAL CIRCUIT [J].

GLUSZKO, P ;

RUCINSKI, B ;

MUSIAL, J ;

WENGER, RK ;

SCHMAIER, AH ;

COLMAN, RW ;

EDMUNDS, LH ;

NIEWIAROWSKI, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (03) :H615-H621

[10]

HOLLOWAY DS, 1988, THROMB HAEMOSTASIS, V59, P62

← 1 2 →