Substrate specificity of human hepatic Udp-glucuronosyltransferases

被引：26

作者：

Burchell, B ^{[1
]}

Lockley, DJ

Staines, A

Uesawa, Y

Coughtrie, MWH

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

[2] Univ Dundee, Ninewells Hosp & Med Sch, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

来源：

PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS | 2005年 / 400卷

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0076-6879(05)00003-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Five human hepatic UDP-glucuronosyltransferases (UGTs) catalyze the facilitated excretion of more than 90% of drugs eliminated by glucuronidation. The substrate specificity of these UGTs has been examined using cloned expressed enzymes and liquid chromatography-mass spectrometry assays to determine the intrinsic clearance of drug glucuronidation in vitro. Specific substrates for the five individual UGTs have been identified. These five probe substrates could be used to predict the drug clearance catalyzed by individual UGTs in vivo.

引用

页码：46 / +

页数：13

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